Li Jianyong Professor
Time：2014-11-10 04:16:00 source： Author：管理员 Click：Time
【摘要】李剑勇，男，1971年12月出生，甘肃秦安人，中共党员，研究员，博士学位，硕士和博士研究生导师，国家百千万人才工程国家级人选，国家有突出贡献中青年专家。1995年毕业于兰州大学
Dr. Jianyong Li
Professor
Lanzhou Institute of Husbandry and Pharmaceutical Science (LIHPS)
Chinese Academy of Agricultural Science (CAAS)
Address: No 335, Jiangouyan, Qilihe district, Lanzhou, 730050, P.R.China
Phone: +86-931-2115290
Fax: +86-931-2115290
E-mail: lijy1971@163.com
Website:www.caas.cn/en
Education Background
Jianyong Li, a medicinal chemist by training, received his BSc degree in pharmacy (1995) from Lanzhou University, China, his MS degree in Clinic Veterinary Sciences (2000) from the Graduate School of Chinese Academy of Agricultural Science, China and his PhD degree in Analytical Chemistry from the Graduate School of Chinese Academy of Science, China.
Research Area
He was leader of research and development program for veterinary chemical pharmaceutical at Agricultural Science and Technology Innovative Program of CAAS, Vice Head at Key Laboratory of Veterinary Pharmaceutical Development of Agricultural Ministry of P.R.China, Key Laboratory of New Animal Drug Project of Gansu Province, Research Centre of New Animal Drug Project of Gansu Province, and the Department of Veterinary Pharmaceutics.
His main research focus is on research and development of novel animal drug, including chemistry, phamacokinetics, pharmacology, toxicology of pharmaceuticals. He has developed a novel drug additive, quinocetone, and finished its residues in edible tissues, which has been widely applied in clinic. He also completed a study in pigs on the PK and quantitative structure-activity relationship of pyroline, an active constituent in a Chinese herb plant. He designed and synthized aspirin eugenol ester (AEE) as a novel drug candidate, and has been carrying on many studies so as to become an approval drug. He was awarded eight China patents on preparations and application of veterinary pharmaceuticals. He has completed 46 research projects as principal investigator. Current research projects include mainly: (a) studies on the chemistry, metabolism and metabolomics, toxicology and pharmacology, pharmacodynamics of AEE; (b) combinatorial technology of separation, selection and identification of the active composition of Chinese traditional herb; (c) anti-virus mechanism of the active composition of a Chinese traditional herb; (d) research and development of Chinese traditional medicinal preparation for curing avian pneusis disease; (e) research and development of new chemical compound for curing pig pneusis disease.
He was awarded the Research Medal of the nation government in 2009 and 2011 for his work on new animal drugs. He is the national middle age and youth prominent contribution specialist and the national selected person of nation hundred, thousand and ten thousand talent project. He leads a veterinary chemical pharmaceutical team which includes one professor, four assistant professors and five lecturers. He supervises the work of two current Ph.D. students and six current MS students, and others supervise the work of three current Ph.D. students and seven current MS students.
Publications
He published more than 190 scientific papers, of which English language papers were more than twenty. His representative publications were as followed:
1. Jianyong Li , Xiaojun Kong, Xiwang Liu, Yajun Yang, Jiyu Zhang.Genotoxic evaluation of aspirin eugenol ester using the Ames test and the mouse bone marrow micronucleus assay.Food and Chemical Toxicology,2013(62): 805-809
2. Ya-Jun Yang, Jian-Yong Li*, Xi-Wang Liu, Ji-Yu Zhang, Yu-Rong Liu, Bing Li. A Non-Biological Method for Screening Active Components against Influenza Virus from Traditional Chinese Medicine by Coupling a LC Column with Oseltamivir Molecularly Imprinted Polymers. Plos One, 2013, 8(12):1-13
3. Jianyong Li , Yuanguang Yu , Yajun Yang, Xiwang Liu , Jiyu Zhang , Bing Li, Xuzheng Zhou,Jianrong Niu, Xiaojuan Wei. A 15-day oral dose toxicity study of aspirin eugenol ester in Wistar rats. Food and Chemical Toxicology, 50 (2012) :1980–1985
4. Jian-yong Li*, Yuan-guang Yu,Qi-wen Wang,Ji-yu Zhang,Ya-jun Yang,Bing Li,Xu-zheng Zhou,Jian-rong Niu, Xiao-juan Wei, Xi-wang Liu,Zhi-qi Liu. Synthesis of aspirin eugenol ester and its biological activity. Medicinal Chemistry Research, 2012,21(7):995-999
5. Jianyong Li1*, Yuanguang Yu, Yajun Yang, Xiwang Liu, Jiyu Zhang, Bing Li, Xuzheng Zhou, Jianrong Niu and Xiaojuan Wei. Antioxidant activity of aspirin eugenol ester for aging model of mice by D-galactose. Journal of Animal and Veterinary Advances, 2012,11(23):4401-4405
6. Ya-jun Yang, Jian-yong Li¬, Yu-rong Liu, Ji-yu Zhang, Bing Li, Xue-peng Cai. Optimization of polymerization parameters for the sorption of oseltamivir onto molecularly imprinted polymers. Analytical and Bioanalytical Chemistry, 2010,400(10):3665-74
7. Xi-Wang Liu, Jian-Yong Li¬, Ya-Jun Yang and Ji-Yu Zhang. 4-Allyl-2-methoxyphenyl-2- acetoxybenzoate. Acta Cryst. (2011). E67, o1621
8. Jianyong Li, Runhua Lu, Aimei Yang, Jiyu Zhang. Syntheses of novel fluoroquinolone compounds. Heterocycl. Commun., 2004, 10(6): 447-450.
9. Jianyong Li, Yunshang Yang, Junxi Liu, Rongcai Zhao, Fenyi Yu, Runhua Lu. Syntheses of [14C]quinocetone. J. Radioanal. Nucl. Chem., 2005,.265(1):17-20
10. Jianyong Li, Rongcai Zhao, Jinshan Li, Runhua Lu. Quinocetone promoting growth in fat chicklings. J. Indian. Veterin., 2005, 82(11):1149-1151.
11. Jianyong Li*, Jiyu Zhang, Xuzheng Zhou, Jin-shan Li, Run-hua Lu.Syntheses of the possible metabolite of quinocetone in animal. Heterocycl.Commun., 2007, 13(1): 49.
12. Jianyong Li*，Jiyu Zhang, Xuzheng Zhou, Ping Zhang, Runhua Lu. Synthesis of [3H]quinocetone. Heterocyclic Communication. 2007,13(3):183~188
13. Rui Wang, Jian-Yong Li, Huan-Yang Qi and Yan-Ping Shi*. Two new tigliane diterpene esters from the flower buds of Daphne genkwa. Journal of Asian Natural Products Research, 2013, DOI:10.1080/10286020.2013.786703
14. Yanbin Shi*, Xiaoyun Zhang, Jianyong Li, Zuoneng Wang, Sen Cheng, Ligang Chen, Yin Qiang, Huili Li, Jingman Ni.reparation and pharmacokinetics of an injectable thermosensitive hydrogel of diminazene aceturate. J. DRUG DEL. SCI. TECH., 23 (6) 531-536 2013
15. Xi-Wang Liu, Han Zhang, Ya-Jun Yang, Jian-Yong Li* and Ji-Yu Zhang. N-(5-Nitro-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide. Acta Cryst. (2013). E69, o943
16. Ji-Yu Zhang,Xu-Zheng Zhou,Bing Li,Ya-Jun Yang,Xiao-Juan Wei,Jian-Rong Niu,Jian-Yong Li,Jin-Shan Li and Xi-Wang Liu.Therapeutic and Persistent Efficacy of Doramectin Against Nematode in Swine Infected Naturally in China. Journal of Animal and Veterinary Advances, 2012,24(11):4684-4688
17. Aimei Yang,Rui Wang,Jianyong Li,Weijie Guo. Chemical Constituents of Saxifraga umbellulata. Advanced Materials Research, 781-784 (2013): 2289-2291
18. Xiaojun KONG, Xiwang LIU, Jianyong LI, Yajun YANG. Advances in Pharmacological Research of Eugenol. Curr Opin Complement Alternat Med 2014,1:1, 8-11.
Professor
Lanzhou Institute of Husbandry and Pharmaceutical Science (LIHPS)
Chinese Academy of Agricultural Science (CAAS)
Address: No 335, Jiangouyan, Qilihe district, Lanzhou, 730050, P.R.China
Phone: +86-931-2115290
Fax: +86-931-2115290
E-mail: lijy1971@163.com
Website:www.caas.cn/en
Education Background
Jianyong Li, a medicinal chemist by training, received his BSc degree in pharmacy (1995) from Lanzhou University, China, his MS degree in Clinic Veterinary Sciences (2000) from the Graduate School of Chinese Academy of Agricultural Science, China and his PhD degree in Analytical Chemistry from the Graduate School of Chinese Academy of Science, China.
Research Area
He was leader of research and development program for veterinary chemical pharmaceutical at Agricultural Science and Technology Innovative Program of CAAS, Vice Head at Key Laboratory of Veterinary Pharmaceutical Development of Agricultural Ministry of P.R.China, Key Laboratory of New Animal Drug Project of Gansu Province, Research Centre of New Animal Drug Project of Gansu Province, and the Department of Veterinary Pharmaceutics.
His main research focus is on research and development of novel animal drug, including chemistry, phamacokinetics, pharmacology, toxicology of pharmaceuticals. He has developed a novel drug additive, quinocetone, and finished its residues in edible tissues, which has been widely applied in clinic. He also completed a study in pigs on the PK and quantitative structure-activity relationship of pyroline, an active constituent in a Chinese herb plant. He designed and synthized aspirin eugenol ester (AEE) as a novel drug candidate, and has been carrying on many studies so as to become an approval drug. He was awarded eight China patents on preparations and application of veterinary pharmaceuticals. He has completed 46 research projects as principal investigator. Current research projects include mainly: (a) studies on the chemistry, metabolism and metabolomics, toxicology and pharmacology, pharmacodynamics of AEE; (b) combinatorial technology of separation, selection and identification of the active composition of Chinese traditional herb; (c) anti-virus mechanism of the active composition of a Chinese traditional herb; (d) research and development of Chinese traditional medicinal preparation for curing avian pneusis disease; (e) research and development of new chemical compound for curing pig pneusis disease.
He was awarded the Research Medal of the nation government in 2009 and 2011 for his work on new animal drugs. He is the national middle age and youth prominent contribution specialist and the national selected person of nation hundred, thousand and ten thousand talent project. He leads a veterinary chemical pharmaceutical team which includes one professor, four assistant professors and five lecturers. He supervises the work of two current Ph.D. students and six current MS students, and others supervise the work of three current Ph.D. students and seven current MS students.
Publications
He published more than 190 scientific papers, of which English language papers were more than twenty. His representative publications were as followed:
1. Jianyong Li , Xiaojun Kong, Xiwang Liu, Yajun Yang, Jiyu Zhang.Genotoxic evaluation of aspirin eugenol ester using the Ames test and the mouse bone marrow micronucleus assay.Food and Chemical Toxicology,2013(62): 805-809
2. Ya-Jun Yang, Jian-Yong Li*, Xi-Wang Liu, Ji-Yu Zhang, Yu-Rong Liu, Bing Li. A Non-Biological Method for Screening Active Components against Influenza Virus from Traditional Chinese Medicine by Coupling a LC Column with Oseltamivir Molecularly Imprinted Polymers. Plos One, 2013, 8(12):1-13
3. Jianyong Li , Yuanguang Yu , Yajun Yang, Xiwang Liu , Jiyu Zhang , Bing Li, Xuzheng Zhou,Jianrong Niu, Xiaojuan Wei. A 15-day oral dose toxicity study of aspirin eugenol ester in Wistar rats. Food and Chemical Toxicology, 50 (2012) :1980–1985
4. Jian-yong Li*, Yuan-guang Yu,Qi-wen Wang,Ji-yu Zhang,Ya-jun Yang,Bing Li,Xu-zheng Zhou,Jian-rong Niu, Xiao-juan Wei, Xi-wang Liu,Zhi-qi Liu. Synthesis of aspirin eugenol ester and its biological activity. Medicinal Chemistry Research, 2012,21(7):995-999
5. Jianyong Li1*, Yuanguang Yu, Yajun Yang, Xiwang Liu, Jiyu Zhang, Bing Li, Xuzheng Zhou, Jianrong Niu and Xiaojuan Wei. Antioxidant activity of aspirin eugenol ester for aging model of mice by D-galactose. Journal of Animal and Veterinary Advances, 2012,11(23):4401-4405
6. Ya-jun Yang, Jian-yong Li¬, Yu-rong Liu, Ji-yu Zhang, Bing Li, Xue-peng Cai. Optimization of polymerization parameters for the sorption of oseltamivir onto molecularly imprinted polymers. Analytical and Bioanalytical Chemistry, 2010,400(10):3665-74
7. Xi-Wang Liu, Jian-Yong Li¬, Ya-Jun Yang and Ji-Yu Zhang. 4-Allyl-2-methoxyphenyl-2- acetoxybenzoate. Acta Cryst. (2011). E67, o1621
8. Jianyong Li, Runhua Lu, Aimei Yang, Jiyu Zhang. Syntheses of novel fluoroquinolone compounds. Heterocycl. Commun., 2004, 10(6): 447-450.
9. Jianyong Li, Yunshang Yang, Junxi Liu, Rongcai Zhao, Fenyi Yu, Runhua Lu. Syntheses of [14C]quinocetone. J. Radioanal. Nucl. Chem., 2005,.265(1):17-20
10. Jianyong Li, Rongcai Zhao, Jinshan Li, Runhua Lu. Quinocetone promoting growth in fat chicklings. J. Indian. Veterin., 2005, 82(11):1149-1151.
11. Jianyong Li*, Jiyu Zhang, Xuzheng Zhou, Jin-shan Li, Run-hua Lu.Syntheses of the possible metabolite of quinocetone in animal. Heterocycl.Commun., 2007, 13(1): 49.
12. Jianyong Li*，Jiyu Zhang, Xuzheng Zhou, Ping Zhang, Runhua Lu. Synthesis of [3H]quinocetone. Heterocyclic Communication. 2007,13(3):183~188
13. Rui Wang, Jian-Yong Li, Huan-Yang Qi and Yan-Ping Shi*. Two new tigliane diterpene esters from the flower buds of Daphne genkwa. Journal of Asian Natural Products Research, 2013, DOI:10.1080/10286020.2013.786703
14. Yanbin Shi*, Xiaoyun Zhang, Jianyong Li, Zuoneng Wang, Sen Cheng, Ligang Chen, Yin Qiang, Huili Li, Jingman Ni.reparation and pharmacokinetics of an injectable thermosensitive hydrogel of diminazene aceturate. J. DRUG DEL. SCI. TECH., 23 (6) 531-536 2013
15. Xi-Wang Liu, Han Zhang, Ya-Jun Yang, Jian-Yong Li* and Ji-Yu Zhang. N-(5-Nitro-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide. Acta Cryst. (2013). E69, o943
16. Ji-Yu Zhang,Xu-Zheng Zhou,Bing Li,Ya-Jun Yang,Xiao-Juan Wei,Jian-Rong Niu,Jian-Yong Li,Jin-Shan Li and Xi-Wang Liu.Therapeutic and Persistent Efficacy of Doramectin Against Nematode in Swine Infected Naturally in China. Journal of Animal and Veterinary Advances, 2012,24(11):4684-4688
17. Aimei Yang,Rui Wang,Jianyong Li,Weijie Guo. Chemical Constituents of Saxifraga umbellulata. Advanced Materials Research, 781-784 (2013): 2289-2291
18. Xiaojun KONG, Xiwang LIU, Jianyong LI, Yajun YANG. Advances in Pharmacological Research of Eugenol. Curr Opin Complement Alternat Med 2014,1:1, 8-11.
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