Quinocetone_Lanzhou Institute Of Husbandry And Pharmaceutical Sciences Of CAAS

Quinocetone

Time：2014-11-10 03:43:14 source： Author：管理员 Click：Time

【摘要】This project belongs to the field of animal husbandry and veterinary science and technology. Quinocetone can be applied to promote growth rate and disease resistance of livestock, poultry and aquatic anima. Its main contents include researc

This project belongs to the field of animal husbandry and veterinary science and technology. Quinocetone can be applied to promote growth rate and disease resistance of livestock, poultry and aquatic anima. Its main contents include research and development, industrialized production, and wide application of the crude drug and premix of quinocetone.
Two new veterinary drug state certificate of the crude drug and premix of quinocetone as animal feed additives products were issued by Ministry of Agriculture in 2003, respectively. They are national first class of new veterinary drugs for chemicals with independent intellectual property rights successfully developed by the three generations of scientific and technological personnel with unremitting efforts for more than 20 years. They are also chemical drugs with national first class certificate of new veterinary drugs issued first since the founding of People Republic of China.
The structure of quinocetone was affirmed. Its materials were easily bought and synthetic procedure was few and easy. Production rate of quinocetone was high and fitted to production. Quinocetone had obvious effect and can make incidence of diarrhea of poultry and livestock to low 50%~70%. The best dosages of quinocetone to promote growth of chickens, pigs, fish were 75ppm, 50ppm and 75ppm，respectively. Similarly, the average increase rates in weight were 17.8%, 15.0% and 30.1%, and the average rate between food and meat in the end of experiment were more 11.8%, 9% and 17.7% than that in the beginning. Quinocetone had no acute, subacute, cumulative, subchronic, chronic, teratogenesis, mutagenesis, carcigenesis toxicity. Quinocetone and its metabolites had no harmful effects on environments. There was very few of quinocetone absorbed into animal body and more than 80 % of quinocetone was excreted from excrement. In 2004, the crude drug and premix of quinocetone were jointly appointed as the national key new product by the four ministries such as Ministry of Science and Technology, Ministry of Commerce, State Environmental Protection Administration, Commission of the State Quality Supervision, Inspection and Quarantine.
Quinocetone can completely substitute Oliquinadox with bigger toxicity and higher residues applied in Chinese husbandry, since Olaquindox has been a feed additive with promoting growth widely used in China. This meet Chinese domestic and foreign demand to veterinary chemicals with efficient, non-toxic and no residual. Its application is advantageous to the production of security food products from animal origin. Quninocetone has enhanced the capacity to earn foreign exchange through exports of animal foods in Chinese country, promoted the healthy and continuous development of animal husbandry and aquaculture in Chinese country, and raised the level of independent research and development of veterinary drugs in Chinese country. Quninocetone has become a new product of veterinary drugs widely used in Chinese animal husbandry and aquaculture.
Up to the end of December 2008, 1929 tons of quinocetone has been produced and applied on pigs, chickens, ducks and aquatic animals cultivation in China. Its application has made economic benefit of 28.3 billion yuan. So quinocetone has extremely remarkable economic and social benefits and broad application prospects.

Scientists

Quinocetone