研究所：032 兰州牧药所

专业学科：基础兽医学

研究方向：兽医药理与毒理学/新兽药研发/新药筛选

导师简介：

李剑勇，男，汉族，1971年12月出生，甘肃秦安人，博士学位，三级研究员，博士生导师，国家有突出贡献中青年专家，国务院政府特殊津贴获得者，中国青年科技奖获得者。现任中国农业科学院科技创新工程兽用化学药物创新团队首席专家，农业部兽用药物创制重点实验室常务副主任，甘肃省新兽药工程重点实验室常务副主任，甘肃省新兽药工程研究中心常务副主任，农业部兽药评审委员会委员，中国兽药典委员会委员，农业部饲料评审委员会委员，中国畜牧兽医学会兽医药理毒理学分会常务理事兼副秘书长，中国毒理学会兽医毒理学专业委员会委员兼副秘书长，甘肃省化学会色谱专业委员会副主任委员，甘肃省高级专家协会理事，甘肃省化学会理事，《黑龙江畜牧兽医杂志》常务编委，《FOOD CHEM》、《Medicinal Chemistry Research》等杂志审稿专家。多年来一直从事兽用药物创制及与之相关的基础和应用基础研究工作，主要研究方向为：兽药设计和筛选的理论、方法与技术；兽药调控机制、质量控制标准与评价方法；新型抗炎、抗菌、抗寄生虫原料药；新型安全高效兽用药物制剂。曾先后完成科研项目40多项，其中主持25项；获得省部级以上奖励10余项；获国家一类新兽药证书2项，三类新兽药证书1项；获国家发明专利17项。发表科技论文250余篇，其中SCI收录论文40篇，第一作者和通讯作者33篇；出版著作4部。培养研究生近30名。

代表性文章：

Mei-Zhou Huang, Ya-Jun Yang, Xi-Wang Liu, Zhe Qin, Jian-Yong Li*. Aspirin eugenol ester attenuates oxidative injury of vascular endothelial cells by regulating NOS and Nrf 2 signaling pathways. British Journal of Pharmacology, 2019. https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bph.14592（IF7.8）

Ning Ma, Jian-Yong Li*, et al. AEE Regulates Cecal Content Metabolomic Profile and Microbiota in an Animal Model of Hyperlipidemia [J]. BMC Veterinary Research, 2018, 14:405（IF1.958）

Ya-Jun Yang, Xi-Wang Liu, Xiao-Jun Kong, Zhe Qin, Zeng-Hua Jiao, Shi-Hong Li and Jian-Yong Li*. Preparation and Evaluation of Oseltamivir Molecularly Imprinted Polymer Silica Gel as Liquid Chromatography Stationary Phase. Molecules, 2018, 23: 1881; doi:10.3390/molecules23081881（IF3.098）

Mei-Zhou Huang, Sheng-Yi Wang, Hui Wang, Dong-An Cui, Ya-Jun Yang, Xi-Wang Liu, Xiao-Jun Kong, Jian-Yong Li*. Differences in the intestinal microbiota between uninfected piglets and piglets infected with porcine epidemic diarrhea virus. PLoS ONE (2018), 13(2): e0192992. https://doi.org/10.1371/journal.pone.0192992（IF2.766）

Ning Ma, Xi-Wang Liu, Xiao-Jun Kong, Zhe Qin, Shi-Hong Li, Zeng-Hua Jiao, Peng-Cheng Dong,Ya-Jun Yang*, Jian-Yong Li*. UPLC-Q-TOF/MS-based urine and plasma metabonomics study on the ameliorative effects of aspirin eugenol ester in hyperlipidemia rats. Toxicology and Applied Pharmacology 332 (2017) 40–51（IF3.791）

Ning Ma, Xiwang Liu, Xiaojun Kong, Shihong Li, Zenghua Jiao, Zhe Qin, Pengcheng Dong, Yajun Yang, and Jianyong Li*.Feces and liver tissue metabonomics studies on the regulatory effect of aspirin eugenol eater in hyperlipidemic rats. Lipids in Health and Disease, (2017) 16:240, DOI 10.1186/s12944-017-0633-0（IF2.663）

Ning Ma, Yajun Yang, Xiwang Liu, Xiaojun Kong, Shihong Li, Zhe Qin, Zenghua Jiao & Jianyong Li*. UPLC-Q-TOF/MS-based metabonomic studies on the intervention effects of aspirin eugenol ester in atherosclerosis hamsters. SCIENTIFIC REPORTS, 2017, 7: 10544. DOI:10.1038/s41598-017-11422-7（IF4.259）

Ning Ma, Xi-Wang Liu, Ya-Jun Yang, Dong-Shuai Shen , Xiao-Le Zhao , Isam Mohamed, Xiao-Jun Kong and Jian-Yong Li*. Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB 2 /6-keto-PGF 1α and blood biochemistry in rat model. BMC Veterinary Research (2016) 12:108. DOI 10.1186/s12917-016-0738-0（IF1.643）

 Ning Ma, Guan-Zhou Yang, Xi-Wang Liu, Ya-Jun Yang, Isam Mohamed, Guang-Rong Liu and Jian-Yong Li* .Impact of Aspirin Eugenol Ester on Cyclooxygenase-1, Cyclooxygenase-2, C-Reactive Protein, Prothrombin and Arachidonate 5-Lipoxygenase in Healthy Rats. Iranian Journal of Pharmaceutical Research (2017), 16 (4): 1443-1451 （IF1.507）

Ya-Jun Yang, Xi-Wang Liu, Bing Li, Shi-Hong Li, Xiao-Jun Kong, Zhe Qin, Jian-Yong Li*. Simultaneous determination of diaveridine, trimethoprim and ormetoprim in feed using high performance liquid chromatography tandem mass spectrometry. Food Chemistry, 2016, 212:358–366. （IF4.052）

Jianyong Li* , Xiaojun Kong, Xiwang Liu, Yajun Yang, Jiyu Zhang.Genotoxic evaluation of aspirin eugenol ester using the Ames test and the mouse bone marrow micronucleus assay. Food and Chemical Toxicology,2013(62): 805-809（IF3.01）

Ning Ma, Xi-Wang Liu, Ya-Jun Yang, Jian-Yong Li*, Isam Mohamed, Guang-Rong Liu, Ji-Yu Zhang. Preventive Effect of Aspirin Eugenol Ester on Thrombosis in κ-Carrageenan-Induced Rat Tail Thrombosis Model. PLOS ONE, DOI:10.1371/journal.pone.0133125 July 20, 2015:1-14（IF3.87）

Isam Karam, Ning Ma, Xi-Wang Liu, Shi-Hong Li, Xiao-Jun Kong, Jian-Yong Li*, Ya-Jun Yang. Regulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia. BMC Veterinary Research, 2015, 11:217. DOI 10.1186/s12917-015-0523-5（IF1.71）

Isam Karam, Ning Ma, Xi-Wang Liu, Xiao-Jun Kong, Xiao-Le Zhao, Ya-Jun Yang and Jian-Yong Li*. Lowering effects of aspirin eugenol ester on blood lipids in rats with high fat diet. Lipids in Health and Disease, 2016, 15:196. DOI 10.1186/s12944-016-0369-2 （IF2.074）

Ya-Jun Yang, Jian-Yong Li*, Xi-Wang Liu, Ji-Yu Zhang, Yu-Rong Liu, Bing Li. A Non-Biological Method for Screening Active Components against Influenza Virus from Traditional Chinese Medicine by Coupling a LC Column with Oseltamivir Molecularly Imprinted Polymers. Plos One, 2013, 8(12):1-13（IF3.87）

Jianyong Li* , Yuanguang Yu , Yajun Yang, Xiwang Liu , Jiyu Zhang , Bing Li, Xuzheng Zhou,Jianrong Niu, Xiaojuan Wei. A 15-day oral dose toxicity study of aspirin eugenol ester in Wistar rats. Food and Chemical Toxicology, 50 (2012) :1980–1985（IF2.999）

Jian-yong Li*, Yuan-guang Yu, Qi-wen Wang, Ji-yu Zhang, Ya-jun Yang, Bing Li, Xu-zheng Zhou,Jian-rong Niu, Xiao-juan Wei, Xi-wang Liu,Zhi-qi Liu. Synthesis of aspirin eugenol ester and its biological activity. Medicinal Chemistry Research, 2012,21(7):995-999 (IF1.612)

Jianyong Li*, Yuanguang Yu, Yajun Yang, Xiwang Liu, Jiyu Zhang, Bing Li, Xuzheng Zhou, Jianrong Niu and Xiaojuan Wei. Antioxidant activity of aspirin eugenol ester for aging model of mice by D-galactose. Journal of Animal and Veterinary Advances, 2012,11(23):4401-4405(IF0.39)

Ya-jun Yang, Jian-yong Li¬, Yu-rong Liu, Ji-yu Zhang, Bing Li, Xue-peng Cai. Optimization of polymerization parameters for the sorption of oseltamivir onto molecularly imprinted polymers. Analytical and Bioanalytical Chemistry, 2011,400(10):3665-74（IF3.874）

Liu X W, Zhang H, Yang YJ, Li JY*, Li B, Zhou XZ & Zhang JY (2014) Synthesis, Antibacterial Evaluation and Molecular Docking Study of Nitazoxanide Analogues. Asia J. Chem. 26 (10):2921-2926(IF0.356)

Youming Shen, Xiwang Liu, Yajun Yang, Jianyong Li*, Ning Ma, Bing Li. In vivo and in vitro metabolism of aspirin eugenol ester in dog byliquid chromatography tandem mass spectrometry. Biomedical Chromatography, 2015, 29: 129-137

Han Zhang, Xiwang Liu, Yajun Yang and Jianyong Li*.Quantitative structure activity relationship (QSAR) studies on nitazoxanide-based analogues against Clostridium difficile In vitro. Pak J Pharm Sci, 2016, 29(5):1681-1689（IF0.682）

联系地址：甘肃省兰州市七里河区硷沟沿335号

电子邮箱：lijy1971@163.com; lijianyong@caas.cn

办公电话：0931-2115290