姓名：杨亚军

研 究 所：兰州牧药所

专业学科：基础兽医学

研究方向：兽医药理与毒理学

导师简介：

杨亚军，男，汉族，1982年9月出生，陕西周至人，博士学位，副研究员，硕士研究生导师。

自2008年4月以来，主要从事兽医药理学、药物筛选、食品安全和兽药新制剂等方面的基础及应用研究。先后主持国家自然科学基金面上项目和青年基金项目各1项，甘肃省自然科学基金和青年基金项目各1项，甘肃省重点研发计划1项，基本科研业务费专项资金项目3项，横向委托项目3项；参与并完成国家自然科学基金面上项目、重点研发计划、甘肃省科技重大专项、农业行业标准制修订项目等十余项。近年来，主要开展了创新药用化合物阿司匹林丁香酚酯的降血脂、预防血栓形成的作用机理及其他相关研究，基于分子印迹技术的非生物学药物筛选方法研究，动物性食品中兽药残留检测方法研究，以及创新兽药制剂的开发等。负责研究所兽药相关的3个省部级科研平台的日常工作，参与完成了各平台及基础兽医学科点的历次评估工作。担任国家自然科学基金评议专家，Frontiers in Pharmacology, Biomedical Chromatography等期刊的审稿专家。

发表论文100余篇，其中以第一作者或通讯作者发表SCI论文10篇，署名发表SCI论文30余篇，中文期刊论文60余篇；主编著作1部，副主编1部，参译1部，参编2部；制定国家标准1项，获得新兽药证书2项；获得发明专利授权12项；获得各级科技奖励6项；合作培养研究生10余名。

代表性论著：

[1] Ning Ma, Isam Karam, Xi-Wang Liu, Xiao-Jun Kong, Zhe Qin, Shi-Hong Li, Zeng-Hua Jiao, Peng-Cheng Dong, Ya-Jun Yang*, Jian-Yong Li*. UPLC-Q-TOF/MS-based urine and plasma metabonomics study on the ameliorative effects of aspirin eugenol ester in hyperlipidemia rats [J]. Toxicology and Applied Pharmacology, 2017, 332: 40-51.

[2] Ning Ma, Xi-Wang Liu, Xiao-Jun Kong, Shi-Hong Li, Zeng-Hua Jiao, Zhe Qin, Ya-Jun Yang*, Jian-Yong Li*. Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia [J]. BMC Veterinary Research, 2018, 14: 405.

[3] Ning Ma, Xiwang Liu, Xiaojun Kong, Shihong Li, Zenghua Jiao, Zhe Qin, Pengcheng Dong, Yajun Yang*, Jianyong Li*. Feces and liver tissue metabonomics studies on the regulatory effect of aspirin eugenol eater in hyperlipidemic rats [J]. Lipids in Health and Disease, 2017, 16: 240.

[4] Isam Karam†, Ning Ma†, Xi-Wang Liu, Xiao-Jun Kong, Xiao-Le Zhao, Ya-Jun Yang*, Jian-Yong Li*. Lowering effects of aspirin eugenol ester on blood lipids in rats with high fat diet [J]. Lipids in Health and Disease, 2016, 15(1): 196.  

[5] Isam Karam, Ning Ma, Xi-Wang Liu, Shi-Hong Li, Xiao-Jun Kong, Jian-Yong Li* and Ya-Jun Yang*. Regulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia [J]. BMC Veterinary Research, 2015, 11: 217.

[6] 马宁，刘希望，孔晓军，李世宏，秦哲，焦增华，杨亚军*，李剑勇*. 长期饲喂高脂饲料对大鼠血脂、肝及肠道菌群的影响[J]. 畜牧兽医学报，2017, 48(7): 1271-80.

[7] Zhen-Dong Zhang, Ya-Jun Yang, Xi-Wang Liu, Zhe Qin, Shi-Hong Li, Jian-Yong Li*. Aspirin eugenol ester ameliorates paraquat-induced oxidative damage through ROS/p38-MAPK-mediated mitochondrial apoptosis pathway [J]. Toxicology, 2021, 453: 152721.

[8] Zhen-Dong Zhang, Ya-Jun Yang, Xi-Wang Liu, Zhe Qin, Shi-Hong Li, Li-Xia Bai, Jian-Yong Li*. The Protective Effect of Aspirin Eugenol Ester on Oxidative Stress to PC12 Cells Stimulated with H2O2 through Regulating PI3K/Akt Signal Pathway [J]. Oxidative Medicine and Cellular Longevity, 2021, Article ID 5527475.

[9] Ning Ma, Yajun Yang, Xiwang Liu, Shihong Li, Zhe Qin, Jianyong Li*. Plasma metabonomics and proteomics studies on the anti-thrombosis mechanism of aspirin eugenol ester in rat tail thrombosis model [J]. Journal of Proteomics, 2020, 215: 103631.

[10] Mei-Zhou Huang, Ya-Jun Yang, Xi-Wang Liu, Zhe Qin, Jian-Yong Li*. Aspirin eugenol ester attenuates oxidative injury of vascular endothelial cells by regulating NOS and Nrf2 signaling pathways [J]. British Journal of Pharmacology, 2019, 176: 906-918.

[11] Mei-Zhou Huang, Ya-Jun Yang, Xi-Wang Liu, Zhe Qin, Jian-Yong Li*. Aspirin Eugenol Ester Reduces H2O2-Induced Oxidative Stress of HUVECs via Mitochondria-Lysosome Axis [J]. Oxidative Medicine and Cellular Longevity, Volume 2019, Article ID 8098135.

[12] Ning Ma, Yajun Yang, Xiwang Liu, Xiaojun Kong, Shihong Li, Zhe Qin, Zenghua Jiao, Jianyong Li*. UPLC-Q-TOF/MS-based metabonomic studies on the intervention effects of aspirin eugenol ester in atherosclerosis hamsters [J]. Scientific Reports, 2017, 7: 10544.

[13] Ya-Jun Yang, Xi-Wang Liu, Bing Li, Shi-Hong Li, Xiao-Jun Kong, Zhe Qin, Jian-Yong Li*. Simultaneous determination of diaveridine, trimethoprim and ormetoprim in feed using high performance liquid chromatography tandem mass spectrometry [J]. Food Chemistry, 2016, 212: 358-366. 

[14] Ya-Jun Yang, Xi-Wang Liu, Xiao-Jun Kong, Zhe Qin, Shi-Hong Li, Zeng-Hua Jiao, Jian-Yong Li*. An LC-MS/MS method for the quantification of diclofenac sodium in dairy cow plasma and its application in pharmacokinetics studies [J]. Biomedical Chromatography, 2019, 33(7): e4520.

[15] Ya-Jun Yang, Xi-Wang Liu, Xiao-Jun Kong, Zhe Qin, Zeng-Hua Jiao, Shi-Hong Li, Jian-Yong Li*. Preparation and Evaluation of Oseltamivir Molecularly Imprinted Polymer Silica Gel as Liquid Chromatography Stationary Phase [J]. Molecules, 2018, 23(8): 1881.

[16] Ya-Jun Yang, Jian-Yong Li*, Xi-Wang Liu, Ji-Yu Zhang, Yu-Rong Liu, Bing Li. A Non-Biological Method for Screening Active Components against Influenza Virus from Traditional Chinese Medicine by Coupling a LC Column with Oseltamivir Molecularly Imprinted Polymers [J]. PLOS ONE, 2013, 8(12): e84458.  

[17] Yajun Yang, Jianyong Li*, Yurong Liu, Jiyu Zhang, Bing Li, Xuepeng Cai. Optimization of polymerization parameters for the sorption of oseltamivir onto molecularly imprinted polymers [J]. Analytical and Bioanalytical Chemistry, 2011, 400(10): 3665-74.

[18] 李剑勇，杨亚军，刘希望，李冰. 饲料中二甲氧苄氨嘧啶、三甲氧苄氨嘧啶和二甲氧甲基苄氨嘧啶的测定  液相色谱—串联质谱法[S]. 中华人民共和国国家标准，农业部2349号公告-8-2015，农业部，发布时间：2015-12-29，实施时间：2016-04-01.

[19] 李剑勇，杨亚军 主编. 天然产物丁香酚的研究与应用[M]. 北京：中国农业科学技术出版社，2016.03，32.5万字.

[20] 李剑勇，刘希望，秦哲 主编；杨亚军，李世宏，孔晓军，等 副主编. 经典老药阿司匹林的研究与应用[M]. 北京：中国农业科学技术出版社，2019.03，62万字.

[21] 兽医药理学与治疗学（第九版），撰稿人，2012年，中国农业出版社，219.2万字（译著）.

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